Immunoelectron Microscopic Localization Of Neural Cell Adhesion Molecules L1, N

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Del Rio JA, Soriano E. Immunocytochemical detection of 5′-bromodeoxyuridine incorporation in the central nervous system of the mouse. Giulian D, Chen J, Ingeman JE, George JK, Noponen M. The position of mononuclear phagocytes in wound therapeutic after traumatic injury to adult mammalian mind. Smith GM, Rutishauser U, Silver J, Miller RH. Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth. Full text is available as a scanned copy of the original print version. Get a printable copy of the entire article (1.6M), or click on on a page picture under to browse web page by page. Links to PubMed are also out there for Selected References. Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG within the growing and adult optic nerve of mice.

Neural Cell Adhesion Molecule N

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After a penetrating lesion within the central nervous system, astrocytes enlarge, divide, and take part in creating an surroundings that adversely affects neuronal regeneration. We have lately shown that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. Animals have been lesioned in the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at defined stereotaxic positions. On one aspect, the lesions were concomitantly infused with N-CAM or with one of many N-CAM-related molecules. As a management, a peptide of the same composition as the N-CAM decapeptide but of random sequence was infused on the contralateral aspect of the mind. The inhibition was biggest within the cortical lesion websites (approximately 50%) and was much less pronounced in the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical sites infused with N-CAM continued to exhibit a significantly smaller inhabitants of dividing astrocytes than the websites on the opposite facet.

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